Endocrine Abstracts

Introduction: Diabetes mellitus is a risk factor for micro-macrovascular complications and increases the risk of hospitalization, and adverse events. Early detection of impending deterioration can prompt interventions and prevent adverse events. Early warning systems (EWS) combined with rapid response teams can mitigate adverse events in the hospital setting. Machine learning-based EWS can use electronic health record data and automatically alert the care team with enough time...

Introduction: YDC is a partnership of four hospital trusts;Kings College Hospital, Princess Royal University Hospital, Lewisham University Hospital and Evelina London Children’s Hospital,caring for a total of 492 children and young people with diabetes. Most young people are on conventional long acting insulin (Levemir and Glargine), but increasingly, poorly controlled patients (HbA1C>100 mmol/mol) with high admission rates are being switched to insulin Degludec due t...

Introduction: Because of the increase of brain image explorations, the prevalence of pituitary tumours has increased a lot. Although most of them have an indolent behaviour, some behave aggressively, demanding a lot of resources for their management. Therefore, it is very important to identify them as soon as possible. The recent WHO 2017 classification of pituitary tumours gives insights into improving their identification using the immunostaining (IS) of transcription factor...

Introduction: Factitious thyrotoxicosis is caused by intentional and surreptitious ingestion of thyroid hormone and can be a challenge in the differential diagnosis with other pathologies.Case report: Female, 35 years old, referred to our department for suspected subacute thyroiditis after COVID-19. The patient had previous medical history of hysterectomy, bilateral oophorectomy, 2 galactophorectomies with right breast reconstruction, depressive syndrome...

Introduction: Continuous glucose monitoring systems (CGM) have revolutionized the monitoring of diabetes, allowing real-time measurement of interstitial glucose levels. Although these devices are suitable for patients on insulin therapy, they are not yet routinely used in an inpatient setting. The difficulty observed in the glycemic control of hospitalized patients under intensive insulin therapy led to the development of a protocol to study the application of CGM in these pat...

Introduction: In 2020, a group of experts proposed to change the term “non-alcoholic fatty liver disease” (NAFLD) to “metabolic-associated fatty liver disease” (MAFLD), which includes hepatic steatosis (HS) (using imaging or analytical scores) associated with overweight or obesity, type 2 diabetes (T2D), or the presence of two other metabolic disorders.Objectives: Analyse the impact of bariatric surgery on MAFLD.<p class="abstext"...

Introduction: Graves’ disease is an autoimmune disease accounting for the majority of hyperthyroidism cases.Aim: We aimed to assess the interrelationships between cardiovascular risk factors, autoimmunity, insulin resistance and treatment in Graves’ disease.Material and methods: We measured free T3 (FT3), free T4 (FT4), TSH, thyrotropin receptor antibodies (TRAb), anti-thyroglobulin and anti-TPO antibodies, thyro...

Introduction: Thyroid dysfunction has been associated with cardiovascular events since it worsens atherogenesis, insulin resistance and dyslipidemia. Thyroid hormones and adipokines interact with each other to regulate metabolism. The impact of thyroid dysfunction on adipokines serum levels remains controversial.Objective: To evaluate the interrelations between thyroid function and cardiovascular risk factors as insulin resistance, lipid profile, inflamm...

Introduction: The interrelationship between autoimmune thyroiditis, Graves’ disease and plasma adipokines levels remains elusive.Aims: We aimed to compare the levels of adiponectin, resistin and PAI-1 levels in patients with autoimmune thyroiditis and Graves’ disease.Subjects and methods: We recorded thyroid function tests, BMI, the levels of total cholesterol (TC), HDL, LDL-cholesterol, triglycerides (TG), apolipoprotein...

Introduction: Myxedema coma is a rare life-threatening clinical condition in patients with longstanding severe untreated hypothyroidism, in whom adaptive mechanisms fail to maintain homeostasis. Most patients, however, are not comatose, and, although strict criteria have been proposed, it is often difficult to differentiate it from very severe hypothyroidism, lacking only a precipitating event.Material and methods: We present the clinical picture of 70 c...